Literature summary for 2.1.1.63 extracted from

Kleibl, K.
Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O6-methylguanine DNA-methyltransferase in other organisms (2002), Mutat. Res., 512, 67-84.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	Escherichia coli	6-O-methylguanine is an important adduct formed by methylating agents, that, if not repaired, can lead to mutations and death. Its repair is carried out by 6-O-methylguanine DNA-methyltransferase. Exposure of E. coli cells to sublethal concentrations of methylating agent triggers the expression of the gene	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Escherichia coli	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?
DNA containing 6-O-methylguanine + [protein]-L-cysteine	6-O-methylguanine is an important adduct formed by methylating agents, that, if not repaired, can lead to mutations and death. Its repair is carried out by 6-O-methylguanine DNA-methyltransferase. Exposure of E. coli cells to sublethal concentrations of methylating agent triggers the expression of the gene	Escherichia coli	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

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Release 2023.1 (January 2023)