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Literature summary for 2.1.1.60 extracted from

  • Haziza, S.; Magnani, R.; Lan, D.; Keinan, O.; Saada, A.; Hershkovitz, E.; Yanay, N.; Cohen, Y.; Nevo, Y.; Houtz, R.L.; Sheffield, V.C.; Golan, H.; Parvari, R.
    Calmodulin methyltransferase is required for growth, muscle strength, somatosensory development and brain function (2015), PLoS Genet., 11, e1005388.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine Mus musculus
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3U2J5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Mus musculus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
calmodulin lysine methyl transferase
-
 Mus musculus
CaM KMT
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice have deficits in motor learning, complex coordination and learning of aversive stimuli Mus musculus
physiological function the enzyme is essential for normal body growth and somatosensory development, as well as for the proper functioning of the adult mouse brain Mus musculus