Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrial gland | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Homo sapiens |
MB-COMT | membrane-bound isoform | Homo sapiens |
S-COMT | soluble isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of COMT expression in endometrial glandular cells results in increased estrogenic milieu and increased estrogen-induced cell proliferation, and increases the propensity of estrogen or catecholestrogens to induce reactive oxygen species, microsatellite instability, and neoplastic transformation of endometrial glandular cells | Homo sapiens |
physiological function | COMT gene expression plays a critical role in modulating the hormonal and carcinogenic effects of estrogen and catecholestrogens and, consequently, modifies the risk for estrogen-induced endometrial cancer | Homo sapiens |