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Literature summary for 2.1.1.6 extracted from

  • Yao, J.; Li, Y.; Chang, M.; Wu, H.; Yang, X.; Goodman, J.E.; Liu, X.; Liu, H.; Mesecar, A.D.; Van Breemen, R.B.; Yager, J.D.; Bolton, J.L.
    Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase (2003), Chem. Res. Toxicol., 16, 668-675.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyequilenin inhibits its own methylation by COMT at higher concentrations in the presence of the reducing agent dithiothreitol, irreversible inhibitor, the inhibitor causes formation of intermolecular disulfide bonds, cys33 in recombinant human soluble COMT is the residue most likely modified by the inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
4-hydroxyequilenin pH 7.8 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 4-hydroxyequilenin
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?

Synonyms

Synonyms Comment Organism
COMT
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
4-hydroxyequilenin pH 7.8 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.026
-
4-hydroxyequilenin pH 7.8, inhibition og methylation of 4-hydroxyestradiol Homo sapiens