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Literature summary for 2.1.1.6 extracted from

  • Huh, M.M.O.; Friedhoff, A.J.
    Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization (1979), J. Biol. Chem., 254, 299-308.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-
soluble
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
COMT I, gel filtration, sedimentation data Rattus norvegicus
47500
-
COMT II, gel filtration, sedimentation data Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
?
additional information Rattus norvegicus physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
?
additional information Oryctolagus cuniculus physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
?
S-adenosyl-L-methionine + a catechol Homo sapiens
-
?
-
?
S-adenosyl-L-methionine + a catechol Rattus norvegicus
-
?
-
?
S-adenosyl-L-methionine + a catechol Oryctolagus cuniculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 forms
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
lung
-
Oryctolagus cuniculus
-
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens
additional information
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, or -60°C, 50 mM Tris-HCl, pH 7.5, 20 mM 2-mercaptoethanol, 20% v/v glycerol, 60-80% of activity retained after 6 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Homo sapiens ?
-
?
additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Rattus norvegicus ?
-
?
additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Oryctolagus cuniculus ?
-
?
S-adenosyl-L-methionine + a catechol
-
Homo sapiens ?
-
?
S-adenosyl-L-methionine + a catechol
-
Rattus norvegicus ?
-
?
S-adenosyl-L-methionine + a catechol
-
Oryctolagus cuniculus ?
-
?