Literature summary for 2.1.1.57 extracted from

Pugh, C.S.G.; Borchardt, R.T.; Stone, H.O.
Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2-)-methyltransferase, and viral multiplication (1978), J. Biol. Chem., 253, 4075-4077.

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Inhibitors

Inhibitors	Comment	Organism	Structure
A9145C	i.e. amino acid modified structure analogue of adenosyl-L-homocysteine, competitive	Vaccinia virus
S-adenosyl-L-homocysteine	product inhibition, competitive	Vaccinia virus
sinefungin	i.e. A9145, competitive	Vaccinia virus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
viral nucleocapsid	-	Vaccinia virus	19013	-

Organism

Organism	UniProt	Comment	Textmining
Vaccinia virus	-	-	-
Vaccinia virus WR	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000134	-	A9145C	-	Vaccinia virus
0.0000194	-	sinefungin	-	Vaccinia virus
0.001	-	S-adenosyl-L-homocysteine	-	Vaccinia virus

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Release 2023.1 (January 2023)