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Literature summary for 2.1.1.57 extracted from

  • Pugh, C.S.G.; Borchardt, R.T.
    Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation (1982), Biochemistry, 21, 1535-1541.
    View publication on PubMed
Search for more literature for 2.1.1.57

Inhibitors

Inhibitors Comment Organism Structure
5',N8-Adenosyl-alpha,beta-diaminobutyric acid moderate Vaccinia virus
A9145C strong Vaccinia virus
S-(2-azaadenosyl)-L-homocysteine
-
 Vaccinia virus
S-(3'-aminoadenosyl)-L-homocysteine
-
 Vaccinia virus
S-(3-deazaadenosyl)-L-homocysteine strong Vaccinia virus
S-(8-azaadenosyl)-L-homocysteine weak Vaccinia virus
S-(N6-Dimethyl-3-deazaadenosyl)-L-homocysteine weak Vaccinia virus
S-(N6-Methyladenosyl)-L-homocysteine
-
 Vaccinia virus
S-Adenosyl-D-homocysteine
-
 Vaccinia virus
S-adenosyl-L-cysteine moderate Vaccinia virus
S-adenosyl-L-homocysteine strong Vaccinia virus
S-Adenosyl-L-homocysteine sulfone strong Vaccinia virus
S-adenosyl-L-homocysteine sulfoxide strong Vaccinia virus
S-Aristeromycinyl-L-homocysteine
-
 Vaccinia virus
S-Cytidyl-L-homocysteine weak Vaccinia virus
S-Inosyl-L-homocysteine weak Vaccinia virus
S-Tubercidinyl-L-homocysteine strong Vaccinia virus
S-Uridyl-L-homocysteine weak Vaccinia virus
sinefungin strong Vaccinia virus

Localization

Localization Comment Organism GeneOntology No. Textmining
viral nucleocapsid
-
 Vaccinia virus 19013
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + m7G(5')pppR-RNA Vaccinia virus final step in formation of 7-methylguanosine(5')pppNm-cap structure of viral RNA S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?
S-adenosyl-L-methionine + m7G(5')pppR-RNA Vaccinia virus WR final step in formation of 7-methylguanosine(5')pppNm-cap structure of viral RNA S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?

Organism

Organism UniProt Comment Textmining
Vaccinia virus
-
-
-
Vaccinia virus WR
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + m7G(5')pppR-RNA
-
 Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?
S-adenosyl-L-methionine + m7G(5')pppR-RNA final step in formation of 7-methylguanosine(5')pppNm-cap structure of viral RNA Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?
S-adenosyl-L-methionine + m7G(5')pppR-RNA
-
 Vaccinia virus WR S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?
S-adenosyl-L-methionine + m7G(5')pppR-RNA final step in formation of 7-methylguanosine(5')pppNm-cap structure of viral RNA Vaccinia virus WR S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000018
-
 A9145C
-
 Vaccinia virus
0.0000075
-
 sinefungin
-
 Vaccinia virus
0.00053
-
 S-adenosyl-L-homocysteine
-
 Vaccinia virus
0.0012
-
 S-Adenosyl-L-homocysteine sulfone
-
 Vaccinia virus
0.0012
-
 S-adenosyl-L-homocysteine sulfoxide
-
 Vaccinia virus
0.0012
-
 S-Tubercidinyl-L-homocysteine
-
 Vaccinia virus
0.0021
-
 S-(3-deazaadenosyl)-L-homocysteine
-
 Vaccinia virus
0.0026
-
 S-Aristeromycinyl-L-homocysteine
-
 Vaccinia virus
0.0046
-
 S-(3'-aminoadenosyl)-L-homocysteine
-
 Vaccinia virus
0.009
-
 S-(N6-Methyladenosyl)-L-homocysteine
-
 Vaccinia virus
0.014
-
 S-Adenosyl-D-homocysteine
-
 Vaccinia virus
0.058
-
 S-adenosyl-L-cysteine
-
 Vaccinia virus