Literature summary for 2.1.1.56 extracted from

Zheng, S.; Shuman, S.
Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site (2008), RNA, 14, 2297-2304.

Protein Variants

Protein Variants	Comment	Organism
D545A	the mutant has 102% of wild type activity	Vaccinia virus
F556A	the mutant has 1% of wild type activity	Vaccinia virus
F556L	the mutant has 3% of wild type activity	Vaccinia virus
N550A	the mutant has 3% of wild type activity	Vaccinia virus
N550D	the mutant has 19% of wild type activity	Vaccinia virus
N550Q	the mutant has 10% of wild type activity	Vaccinia virus
R548A	the mutant has 59% of wild type activity	Vaccinia virus
R560A	the mutant has 18% of wild type activity	Vaccinia virus
R560K	the mutant has 84% of wild type activity	Vaccinia virus
R560Q	the mutant has 84% of wild type activity	Vaccinia virus
R562A	the mutant has 10% of wild type activity	Vaccinia virus
R562K	the mutant has 25% of wild type activity	Vaccinia virus
R562Q	the mutant has 23% of wild type activity	Vaccinia virus
R655A	the mutant has 31% of wild type activity	Vaccinia virus
R794A	the mutant has 124% of wild type activity	Vaccinia virus
R808A	the mutant has 142% of wild type activity	Vaccinia virus
Y555A	the mutant has 2% of wild type activity	Vaccinia virus
Y555F	the mutant has 94% of wild type activity	Vaccinia virus
Y555L	the mutant has 2% of wild type activity	Vaccinia virus
Y555S	the mutant has 4% of wild type activity	Vaccinia virus

Organism	UniProt	Comment	Textmining
Vaccinia virus	-	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA	-	Vaccinia virus	S-adenosyl-L-homocysteine + m7G(5')pppR-RNA	-	?

Synonyms	Comment	Organism
mRNA cap (guanine-N7) methyltransferase	-	Vaccinia virus