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Literature summary for 2.1.1.56 extracted from

  • Shafer, B.; Chu, C.; Shatkin, A.J.
    Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability (2005), Mol. Cell. Biol., 25, 2644-2649.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
complementation of knock-down HeLa S3 cells with enzymatically active N-truncated enzyme comprising residues 120-476 and being located at the nucleus, no complementation of knock-down HeLa S3 cells with enzymatically active N-truncated enzyme comprising residues 144-476 and being loacetd mainly in the cytoplasm, truncated enzymes are expresss in fusion with GFP Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of knock-down HeLa cells S3, gene inactivation by small interference RNA in HeLa cells results in apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus nuclear localization is required for cell viability, targeting localization signal sequences are 80KKRK, 103KKRKR, and 126KRK Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA Homo sapiens essential for cell viability S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA
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Homo sapiens S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
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?
S-adenosyl-L-methionine + G(5')pppR-RNA essential for cell viability Homo sapiens S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
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?

Synonyms

Synonyms Comment Organism
mRNA cap methyltransferase
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Homo sapiens