Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5',N8-Adenosyl-alpha,beta-diaminobutyric acid | moderate | Vaccinia virus | |
amino acid modified structure analogue of adenosyl-L-homocysteine | i.e. A9145C, strong | Vaccinia virus | |
additional information | no inhibition by S-uridinyl-L-homocysteine, S-cytidinyl-L-homocysteine | Vaccinia virus | |
S-(2-azaadenosyl)-L-homocysteine | moderate | Vaccinia virus | |
S-(3-Aminoadenosyl)-L-homocysteine | weak | Vaccinia virus | |
S-(3-deazaadenosyl)-L-homocysteine | strong | Vaccinia virus | |
S-(8-azaadenosyl)-L-homocysteine | weak | Vaccinia virus | |
S-(N6-Dimethyl-3-deazaadenosyl)-L-homocysteine | weak | Vaccinia virus | |
S-(N6-Methyladenosyl)-L-homocysteine | moderate | Vaccinia virus | |
S-Adenosyl-D-homocysteine | weak | Vaccinia virus | |
S-adenosyl-L-cysteine | moderate | Vaccinia virus | |
S-adenosyl-L-homocysteine | product inhibition, competitive | Vaccinia virus | |
S-Adenosyl-L-homocysteine structural analogues | - |
Vaccinia virus | |
S-Adenosyl-L-homocysteine sulfone | weak | Vaccinia virus | |
S-adenosyl-L-homocysteine sulfoxide | weak | Vaccinia virus | |
S-Aristeromycinyl-L-homocysteine | - |
Vaccinia virus | |
S-Inosyl-L-homocysteine | weak | Vaccinia virus | |
S-Tubercidinyl-L-homocysteine | weak | Vaccinia virus | |
sinefungin | i.e. A9145, strong | Vaccinia virus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
viral nucleocapsid | - |
Vaccinia virus | 19013 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + G(5')pppR-RNA | Vaccinia virus | R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | - |
? | |
S-adenosyl-L-methionine + G(5')pppR-RNA | Vaccinia virus WR | R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vaccinia virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + G(5')pppR-RNA | - |
Vaccinia virus | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap | ? | |
S-adenosyl-L-methionine + G(5')pppR-RNA | R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA | Vaccinia virus | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | - |
? | |
S-adenosyl-L-methionine + G(5')pppR-RNA | - |
Vaccinia virus WR | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap | ? | |
S-adenosyl-L-methionine + G(5')pppR-RNA | R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA | Vaccinia virus WR | S-adenosyl-L-homocysteine + m7G(5')pppR-RNA | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Vaccinia virus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Vaccinia virus |