Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastocyst | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | in blastocysts, mean inner cell numbers decrease from18-19 in controls to 11-13 when the folate cycle is inhibited by the antifolate methotrexate and to 12-14 when BHMT expression is knocked down by antisense morpholinos. Inhibiting both pathways more severely affects inner cellmass development (7-8 cells).Total SAM levels in mouse blastocysts decrease significantly only when both pathways are inhibited (from 3.1 to 1.6 pmol/100 blastocysts). DNA methylation is minimally affected by inhibition of either pathway alone but decreases by at least 45-55% when both BHMT and the folate cycle are inhibited simultaneously | Mus musculus |