Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AdoMet | weak inhibitor, at 2 mM: 24% inhibition | Homo sapiens | |
AdoMet | weak inhibitor, at 2.5 mM: 15% inhibition | Mus musculus | |
dimethylglycine | at 0.2 mM: 80% inhibition, at 2 mM: 97% inhibition; weak inhibitor, at 2 mM: 11% inhibition | Homo sapiens | |
dimethylglycine | at 0.25 mM: 64% inhibition, at 2.5 mM: 95% inhibition; weak inhibitor, at 2.5 mM: 19% inhibition | Mus musculus | |
dimethylsulfonioacetate | at 2 mM: 79% inhibition; weak inhibitor, at 2 mM: 20% inhibition | Homo sapiens | |
dimethylsulfonioacetate | at 0.25 mM: 29% inhibition, at 2.5 mM: 82% inhibition | Mus musculus | |
dimethylsulfoniopropionate | weak inhibitor, at 2 mM: 29% inhibition | Homo sapiens | |
dimethylsulfoniopropionate | weak inhibitor, at 2.5 mM: 11% inhibition; weak inhibitor, at 2.5 mM: 17% inhibition | Mus musculus | |
methionine | at 2 mM: 60% inhibition; weak inhibitor at 2 mM: 15% inhibition | Homo sapiens | |
methionine | at 2.5 mM: 38% inhibition; at 2.5 mM: 48% inhibition | Mus musculus | |
S-(delta-carboxybutyl)-L-homocysteine | at 0.05 mM: 97% inhibition, at 0.5 mM: total inhibition; weak inhibitor, at 0.5 mM: 26% inhibition | Homo sapiens | |
S-(delta-carboxybutyl)-L-homocysteine | at 0.025 mM: 22% inhibition, at 0.0625 mM: 36% inhibition, at 0.125 mM: 49% inhibition, at 0.5 mM: 81% inhibition; total inhibition | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.76 | - |
S-methyl-L-methionine | - |
Mus musculus | |
0.94 | - |
S-methyl-L-methionine | - |
Homo sapiens | |
2.2 | - |
betaine | - |
Homo sapiens | |
3 | - |
S-methyl-L-methionine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn | BHMT-2 is a zinc metalloenzyme | Mus musculus | |
Zn | BHMT-2 is a zinc metalloenzyme | Homo sapiens | |
Zn2+ | BHMT is a zinc metalloenzyme | Homo sapiens | |
Zn2+ | BHMT-2 is a zinc metalloenzyme | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homocysteine + betaine | - |
Mus musculus | L-methionine + dimethylglycine | - |
? | |
L-homocysteine + betaine | - |
Homo sapiens | L-methionine + dimethylglycine | - |
? | |
L-homocysteine + S-methyl-L-methionine | - |
Mus musculus | ? | - |
? | |
L-homocysteine + S-methyl-L-methionine | - |
Homo sapiens | ? | - |
? | |
L-homocysteine + S-methyl-L-methionine | BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine | Homo sapiens | ? | - |
? | |
L-homocysteine + S-methylmethionine | BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
betaine-homocysteine S-methyltransferase | - |
Mus musculus |
betaine-homocysteine S-methyltransferase | - |
Homo sapiens |
betaine-homocysteine S-methyltransferase-2 | - |
Mus musculus |
betaine-homocysteine S-methyltransferase-2 | - |
Homo sapiens |
BHMT | - |
Mus musculus |
BHMT | - |
Homo sapiens |
BHMT-2 | - |
Homo sapiens |
BHMT2 | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
24 | - |
S-methyl-L-methionine | - |
Homo sapiens | |
38 | - |
S-methyl-L-methionine | - |
Homo sapiens | |
88 | - |
betaine | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |