Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | triamcinolone increases the level and rate of BHMT mRNA synthesis in H4IIE cells | Rattus norvegicus | |
streptozotocin | increases BHMT activity and mRNA levels in the liver | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | decreased plasma homocysteine in various models of diabetes may be due to enhanced homocysteine removal brought about by a combination of increased transsulfuration of homocysteine to cysteine and increased remethylation of homocysteine to methionine by BHMT | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | insulin decreases the abundance of BHMT mRNA and the rate of de novo mRNA transcription of the gene in H4IIE cells, plays a direct role in the regulation of BHMT transcription | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H4IIE cell | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homocysteine + betaine | - |
Rattus norvegicus | L-methionine + dimethylglycine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
betaine-homocysteine methyltransferase | - |
Rattus norvegicus |
BHMT | - |
Rattus norvegicus |