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Literature summary for 2.1.1.5 extracted from

  • Ratnam, S.; Wijekoon, E.P.; Hall, B.; Garrow, T.A.; Brosnan, M.E.; Brosnan, J.T.
    Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver (2006), Am. J. Physiol. Endocrinol. Metab., 290, E933-E939.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information triamcinolone increases the level and rate of BHMT mRNA synthesis in H4IIE cells Rattus norvegicus
streptozotocin increases BHMT activity and mRNA levels in the liver Rattus norvegicus

Application

Application Comment Organism
medicine decreased plasma homocysteine in various models of diabetes may be due to enhanced homocysteine removal brought about by a combination of increased transsulfuration of homocysteine to cysteine and increased remethylation of homocysteine to methionine by BHMT Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information insulin decreases the abundance of BHMT mRNA and the rate of de novo mRNA transcription of the gene in H4IIE cells, plays a direct role in the regulation of BHMT transcription Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H4IIE cell
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homocysteine + betaine
-
Rattus norvegicus L-methionine + dimethylglycine
-
?

Synonyms

Synonyms Comment Organism
betaine-homocysteine methyltransferase
-
Rattus norvegicus
BHMT
-
Rattus norvegicus