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Literature summary for 2.1.1.41 extracted from

  • Renard, D.; Perruchon, J.; Giera, M.; Mueller, J.; Bracher, F.
    Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis (2009), Bioorg. Med. Chem., 17, 8123-8137.
    View publication on PubMed
Search for more literature for 2.1.1.41

Inhibitors

Inhibitors Comment Organism Structure
(3S,20R)-20-(propylamino-ethyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-(butylamino-methyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-(ethylamino-methyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-(methylamino-methyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-(pentylamino-methyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-(propylamino-methyl)-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-[(1R,S)-(1,2-dimethyl-propylamino)-methyl]-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-[(2-dimethylamino-ethylamino)-methyl]-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-[(2-methylpropyl)amino-methyl]-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-[(2-pyrrolidin-1-yl-ethylamino)-methyl]-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(3S,20S)-20-[(3-dimethylamino-propylamino)-methyl]-pregn-7-en-3-ol
-
 Yarrowia lipolytica
(R,S)-S-butyl-S-[(3S,20S)-(3-hydroxypregn-7-en-20-yl)-methyl]-S-methyl-sulfonium iodide
-
 Yarrowia lipolytica
2-(3S,20R)-[(E)-2-(3-hydroxypregn-7-en-20-yl)-ethenyl]-1-methylpyridinium iodide
-
 Yarrowia lipolytica
23-Azacholesterol
-
 Yarrowia lipolytica
4-(3S,20R)-[(E)-2-(3-hydroxypregn-7-en-20-yl)-ethenyl]-1-methylpyridinium iodide
-
 Yarrowia lipolytica
ketoconazole
-
 Yarrowia lipolytica

Organism

Organism UniProt Comment Textmining
Yarrowia lipolytica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
14alpha-methylergosta-8,24(28)-diene + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
5-dehydroepisterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
cholesta-5,7,24-triene + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
cholesta-7,24-diene + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
cholesterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
dehydroergosterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
ergosta-5,8,22,24(28)-tetraene + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
ergosterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?
lanosterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
-
 ?
zymosterol + S-adenosyl-L-methionine
-
 Yarrowia lipolytica ?
-
 ?

Synonyms

Synonyms Comment Organism
24-SMT
-
 Yarrowia lipolytica
DELTA24-sterol methyltransferase
-
 Yarrowia lipolytica

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Yarrowia lipolytica

General Information

General Information Comment Organism
metabolism key enzyme in the biosynthesis of ergosterol Yarrowia lipolytica