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Literature summary for 2.1.1.41 extracted from

  • Jimenez-Jimenez, C.; Carrero-Lerida, J.; Sealey-Cardona, M.; Ruiz Perez, L.M.; Urbina, J.A.; Gonzalez Pacanowska, D.
    Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme (2008), Mol. Biochem. Parasitol., 160, 52-59.
    View publication on PubMed
Search for more literature for 2.1.1.41

Protein Variants

Protein Variants Comment Organism
additional information Leishmania major promastigotes cells overproducing the enzyme do not have increased resistance to the sterol methenyltransferase inhibitor 22,26-azasterol Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
22,26-azasterol
-
 Leishmania major
ketoconazole
-
 Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum by immunofluorescence and electron microscopy studies it is shown that sterol methenyltransferase is primarily associated to the endoplasmic reticulum. In addition to this localisation, the protein is incorporated into translucent vesicles presumably of the endocytic pathway Leishmania major 5783
-

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmosterol + S-adenosyl-L-methionine
-
 Leishmania major 24-methylenedesmosterol + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
SMT
-
 Leishmania major

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0035
-
-
 Leishmania major 22,26-azasterol
0.00383
-
-
 Leishmania major ketoconazole