Activating Compound | Comment | Organism | Structure |
---|---|---|---|
amphotericine B | activates at concentrations below 5.4 nM, optimal at 2.1 nM, wild-type and mutant | Kluyveromyces lactis | |
candicidin | stimulates, best at low concentration | Kluyveromyces lactis | |
Filipin | slightly activating at high concentration | Kluyveromyces lactis | |
Nystatin | slightly activating at high concentration | Kluyveromyces lactis | |
pimaricin | strong activation, activation level decreases with increasing concentration of pimaricin | Kluyveromyces lactis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | natural amphotericine B-resistant mutant strain | Kluyveromyces lactis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amphotericine B | inhibits the wild-type at concentrations above 60 nM, inhibition can be hindered by zymosterol | Kluyveromyces lactis | |
Filipin | slightly inhibiting at low concentration | Kluyveromyces lactis | |
Nystatin | slightly inhibiting at low concentration | Kluyveromyces lactis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
zymosterol + S-adenosyl-L-methionine | Kluyveromyces lactis | - |
fecosterol + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Kluyveromyces lactis | - |
yeast | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
zymosterol + S-adenosyl-L-methionine | - |
Kluyveromyces lactis | fecosterol + S-adenosyl-L-homocysteine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | - |
assay at | Kluyveromyces lactis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Kluyveromyces lactis |