Any feedback?
Literature summary for 2.1.1.41 extracted from
- Studies on the activity of Kluyveromyces lactis S-adenosylmethionine:DELTA 24-sterol methyltransferase in presence of polyenic antifungal agents (1994), Mycopathologia, 126, 75-83.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| amphotericine B | activates at concentrations below 5.4 nM, optimal at 2.1 nM, wild-type and mutant | Kluyveromyces lactis |  |
| candicidin | stimulates, best at low concentration | Kluyveromyces lactis | |
| Filipin | slightly activating at high concentration | Kluyveromyces lactis | |
| Nystatin | slightly activating at high concentration | Kluyveromyces lactis | |
| pimaricin | strong activation, activation level decreases with increasing concentration of pimaricin | Kluyveromyces lactis | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | natural amphotericine B-resistant mutant strain | Kluyveromyces lactis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amphotericine B | inhibits the wild-type at concentrations above 60 nM, inhibition can be hindered by zymosterol | Kluyveromyces lactis | |
| Filipin | slightly inhibiting at low concentration | Kluyveromyces lactis | |
| Nystatin | slightly inhibiting at low concentration | Kluyveromyces lactis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| zymosterol + S-adenosyl-L-methionine | Kluyveromyces lactis | - |
fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Kluyveromyces lactis | - |
yeast | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| zymosterol + S-adenosyl-L-methionine | - |
Kluyveromyces lactis | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
assay at | Kluyveromyces lactis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Kluyveromyces lactis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
