Literature summary for 2.1.1.4 extracted from

Tedesco, S.C.; Moron, D.J.; Reiter, R.J.
Hydroxyindole-O-methyltransferase activity in the pineal gland of the muskox (Ovibos moschatus) (1994), J. Pineal Res., 16, 121-126.

Search for more literature for 2.1.1.4

Inhibitors

Inhibitors	Comment	Organism	Structure
N-acetylserotonin	-	Ovibos moschatus
S-adenosyl-L-homocysteine	-	Ovibos moschatus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	N-acetylserotonin	-	Ovibos moschatus

Organism

Organism	UniProt	Comment	Textmining
Ovibos moschatus	-	muskox	-

Reaction

Reaction	Comment	Organism	Reaction ID
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin	addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin	Ovibos moschatus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
pineal gland	-	Ovibos moschatus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + N-acetylserotonin	-	Ovibos moschatus	S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.2	-	-	Ovibos moschatus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.042	-	N-acetylserotonin	-	Ovibos moschatus

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Release 2023.1 (January 2023)