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Literature summary for 2.1.1.37 extracted from

  • Hussain, S.; Tuorto, F.; Menon, S.; Blanco, S.; Cox, C.; Flores, J.V.; Watt, S.; Kudo, N.R.; Lyko, F.; Frye, M.
    The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation (2013), Mol. Cell. Biol., 33, 1561-1570.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.37

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatoid
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q1HFZ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
NSUN2
-
 Mus musculus

General Information

General Information Comment Organism
physiological function NSun2 is essential for germ cell differentiation in the mouse testis. In NSun2-depleted testes, genes encoding Ddx4, Miwi, and Tudor domain-containing proteins are repressed. Loss of NSun2 specifically blocks meiotic progression of germ cells into the pachytene stage. The same phenotype is observed when NSun2 and Dnmt2, the only other cytosine-5 RNA methyltransferase characterized to date, are deleted simultaneously. Specific NSun2- and Dnmt2-methylated tRNAs decrease in abundance when both methyltransferases are deleted Mus musculus