Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | Mus musculus | major enzyme in maintenance of the pattern of DNA methylation after DNA replication | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P13864 | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | major enzyme in maintenance of the pattern of DNA methylation after DNA replication | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + DNA | methylates DNA processively with high preference for hemimethylated target sites. Dnmt1 methylates a hemimethylated 958-mer substrate in a highly processive reaction. Fully methylated and unmethylated CG sites do not inhibit processive methylation of the DNA. Unmethylated sites embedded in a hemimethylated context are modified at an approximately 24fold reduced rate. Completely unmodified DNA is methylated even more slowly. Dnmt1 is not able to methylate hemimethylated CG sites on different strands of the DNA in a processive manner, indicating that Dnmt1 keeps its orientation with respect to the DNA while methylating the CG sites on one strand of the DNA | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt1 DNA-(cytosine-C5)-methyltransferase | - |
Mus musculus |