Application | Comment | Organism |
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medicine | an RNA preparation of an Escherichia coli trmH mutant that lacks Gm18 2'-O-methyltransferase activity is significantly more immunostimulatory in human peripheral blood mononuclear cells than the wild-type sample. The single methyl group on the 2'-oxygen of Gm18 is a natural modification in native tRNA that, beyond its primary structural role, has acquired a secondary function as an antagonist of toll-like receptor TLR7 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
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Escherichia coli | - |
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- |