Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of enzyme knockout mutant mice, that show resting cardiovascular function, including blood pressure, heart rate, and cardiac output similar to that in wild-type mice, and the basal norepinephrine plasma level is unaltered. However, inhibition of sympathetic innervation with the ganglion blocker hexamethonium causes a 54% smaller decrease in blood pressure in KO mice compared to wild-type mice, and treadmill exercise causes an 11% higher increase in blood pressure, both suggesting impaired vasodilation in KO mice, the enzyme knockout does not change the heart rate response to ganglionic blockade and exercise. KO mice have an increased ratio of left ventricular posterior wall thickness to internal dimensions but do not have cardiac hypertrophy, in restrained, awake KO mice, heart rate and ejection fraction remain unaltered, but cardiac output is significantly reduced because of diminished end-diastolic volume, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
intracellular | - |
Mus musculus | 5622 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + norepinephrine | Mus musculus | epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest | S-adenosyl-L-homocysteine + epinephrine | - |
? | |
S-adenosyl-L-methionine + norepinephrine | Mus musculus C57BL/6 | epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest | S-adenosyl-L-homocysteine + epinephrine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
additional information | activity tissue distribution, overview | Mus musculus | - |
plasma | - |
Mus musculus | - |
urine | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity tissue distribution, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + norepinephrine | - |
Mus musculus | S-adenosyl-L-homocysteine + epinephrine | - |
? | |
S-adenosyl-L-methionine + norepinephrine | epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest | Mus musculus | S-adenosyl-L-homocysteine + epinephrine | - |
? | |
S-adenosyl-L-methionine + norepinephrine | - |
Mus musculus C57BL/6 | S-adenosyl-L-homocysteine + epinephrine | - |
? | |
S-adenosyl-L-methionine + norepinephrine | epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest | Mus musculus C57BL/6 | S-adenosyl-L-homocysteine + epinephrine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |