Literature summary for 2.1.1.28 extracted from

Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Criscione, K.R.
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor (1999), J. Med. Chem., 42, 3315-3323.

Search for more literature for 2.1.1.28

Inhibitors

Inhibitors	Comment	Organism	Structure
3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
3-trifluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-methylsulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	-	Bos taurus	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00052	-	3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.002	-	3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.013	-	3-trifluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.015	-	3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.036	-	7-methylsulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus

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Release 2023.1 (January 2023)