Literature summary for 2.1.1.28 extracted from

Grunewald, G.L.; Dahanukar, V.H.; Jalluri, R.K.; Criscione, K.R.
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the a2-adrenoceptor (1999), J. Med. Chem., 42, 118-134.

Search for more literature for 2.1.1.28

Inhibitors

Inhibitors	Comment	Organism	Structure
1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid	-	Bos taurus
7-acetamido-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-allylsulfonyl-1,2,3,4-tetrahydrosioquinoline	-	Bos taurus
7-aminocarbonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-aminomethyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride	-	Bos taurus
7-benzoyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-benzyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-bromo-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline oxalate	-	Bos taurus
7-iodo-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-methylsulfinyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-methylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-methylthio-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-trichloromethylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
additional information	7-substituted-1,2,3,4-tetrahydroisoquinolines are potent inhibitors, unfortunately, most of these compounds also exhibit a strong affinity for the alpha2-adrenoreceptor	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Bos taurus	enzyme is involved in biosynthesis of epinephrine	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal medulla	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is involved in biosynthesis of epinephrine	Bos taurus	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00018	-	7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.00029	-	7-bromo-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.00037	-	7-iodo-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.00061	-	7-methylthio-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0013	-	7-methylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0013	-	7-trichloromethylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0029	-	7-benzoyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0057	-	7-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0067	-	7-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.0098	-	7-allylsulfonyl-1,2,3,4-tetrahydrosioquinoline	-	Bos taurus
0.011	-	7-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline oxalate	-	Bos taurus
0.014	-	7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.045	-	7-methylsulfinyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.061	-	7-benzyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.064	-	7-aminocarbonyl-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.19	-	7-acetamido-1,2,3,4-tetrahydroisoquinoline	-	Bos taurus
0.47	-	1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid	-	Bos taurus
1.9	-	7-aminomethyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)