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Literature summary for 2.1.1.22 extracted from

  • Drozak, J.; Chrobok, L.; Poleszak, O.; Jagielski, A.K.; Derlacz, R.
    Molecular identification of carnosine N-methyltransferase as chicken histamine N-methyltransferase-like protein (HNMT-like) (2013), PLoS ONE, 8, e64805.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.22

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 and HEK-293T cells Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.646
-
 carnosine pH 7.5, 37°C Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36375
-
 1 * 36375, calculated, 1 * 38000, gel filtration of recombinant protein Gallus gallus
38000
-
 1 * 36375, calculated, 1 * 38000, gel filtration of recombinant protein Gallus gallus
45000
-
 gel filtration Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus U3NEE3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle pectoral muscle Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information very poor substrates: anserine, imidazole-4-acetic acid, imidazole-4-acrylic acid, L-histidine, histamine, imidazole Gallus gallus ?
-
 ?
S-adenosyl-L-methionine + carnosine
-
 Gallus gallus S-adenosyl-L-homocysteine + anserine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 36375, calculated, 1 * 38000, gel filtration of recombinant protein Gallus gallus

Synonyms

Synonyms Comment Organism
carnosine N-methyltransferase 2
-
 Gallus gallus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.008
-
 carnosine pH 7.5, 37°C Gallus gallus
0.011
-
 S-adenosyl-L-methionine pH 7.5, 37°C Gallus gallus