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Literature summary for 2.1.1.204 extracted from

  • Burgess, A.; David, R.; Searle, I.
    Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae (2015), BMC Plant Biol., 15, 199.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.204

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine38 in tRNAAsp(GTC) Arabidopsis thaliana
-
 S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp(GTC)
-
 ?
S-adenosyl-L-methionine + cytosine38 in tRNAGly(GCC) Arabidopsis thaliana
-
 S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly(GCC)
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine38 in tRNAAsp(GTC)
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp(GTC)
-
 ?
S-adenosyl-L-methionine + cytosine38 in tRNAGly(GCC)
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly(GCC)
-
 ?

Synonyms

Synonyms Comment Organism
DNA methyltransferase 2
-
 Arabidopsis thaliana
Dnmt2
-
 Arabidopsis thaliana
transfer RNA aspartic acid methyltransferase 1
-
 Arabidopsis thaliana
TRDMT1
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview. Both the nucleotide position and percent methylation of tRNAs and rRNAs cytosine 5-methylation sites are conserved across all species analysed, overview Arabidopsis thaliana
malfunction trdmt1/trm4b double mutants are hypersensitive to the antibiotic hygromycin B. Non-methylated C38 in trdmt1-defective plants results in loss of HpyCH4IV restriction site Arabidopsis thaliana
physiological function post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine is an important modification that regulates RNA metabolism. Identification of cytosine 5-methylation sites in nuclear, chloroplast and mitochondrial tRNAs. Nuclear tRNA methylation requires two evolutionarily conserved methyltransferases, TRDMT1 and TRM4B, EC 2.1.1.202 Arabidopsis thaliana