Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | granular cytoplasmic distribution with minor signals in the nucleus. Large structures appear in the cytoplasm and in the nucleus upon heat stress | Drosophila melanogaster | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytosine38 in tRNA | Drosophila melanogaster | RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9U6H7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Drosophila melanogaster | - |
larva | - |
Drosophila melanogaster | - |
ovary | - |
Drosophila melanogaster | - |
S2 cell | - |
Drosophila melanogaster | - |
testis | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytosine38 in tRNA | RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage | Drosophila melanogaster | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNA | methylation of cytosine 38 in the anti-codon lopp of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Other C38-containing tRNAs-including tRNAMet(ATG), tRNAGlu(CTC), and tRNAHis(GTG) are not detectably methylated in a Dnmt2-dependent manner | Drosophila melanogaster | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt2 | - |
Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | Drosophila Dnmt2 mutants show reduced viability under stress conditions, and Dnmt2 relocalizes to stress granules following heat shock | Drosophila melanogaster |
physiological function | RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease | Drosophila melanogaster |