Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAMT | - |
Mus musculus |
guanidinoacetate methyltransferase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | both RNA and protein levels of GAMT are increased in a p53-dependent manner after various inducers of genotoxic stress (etoposide, H2O2, and gamma-irradiation), glucose deprivation induces GAMT in a p53-dependent manner, GAMT mRNA and protein are increased in several tissues of glucose-deprived p53 wild-type mice while remaining unchanged in the same tissues of p53 null mice | up |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of GAMT causes a creatine deficiency syndrome that is characterized by neurological and motor dysfunction as well as developmental delay/regression, mental retardation, and related defects | Mus musculus |