Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
astrocyte | - |
Homo sapiens | - |
brain | expressed within the brain, both during development and in adulthood | Mus musculus | - |
brain | expressed within the brain, both during development and in adulthood | Homo sapiens | - |
central nervous system | - |
Mus musculus | - |
central nervous system | - |
Homo sapiens | - |
cerebral gray matter | - |
Mus musculus | - |
cerebral gray matter | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
additional information | not expressed in microcapillary endothelial cells | Mus musculus | - |
additional information | not expressed in microcapillary endothelial cells | Homo sapiens | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
oligodendrocyte | - |
Mus musculus | - |
oligodendrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | - |
Homo sapiens | S-adenosyl-L-homocysteine + creatine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAMT | - |
Mus musculus |
GAMT | - |
Homo sapiens |
guanidinoacetate methyltransferase | - |
Mus musculus |
guanidinoacetate methyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | GAMT-cerebrospinal fluid knockout mice show decreased levels of creatine within their brain, which however still reach 1.4 mM or 0.4-0.5 mol/g of tissue, and a very significant increase in guanidinoacetate (1.9 mol/g tissue), GAMT knockout mice slowly replenish their brain creatine upon creatine treatment | Mus musculus |
malfunction | GAMT-deficient patients have strongly decreased levels of creatine in cerebrospinal fluid but are able to import creatine from the blood | Homo sapiens |