Literature summary for 2.1.1.17 extracted from

Presa, N.; Clugston, R.D.; Lingrell, S.; Kelly, S.E.; Merrill, A.H.; Jana, S.; Kassiri, Z.; Gomez-Munoz, A.; Vance, D.E.; Jacobs, R.L.; van der Veen, J.N.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice (2019), Biochim. Biophys. Acta, 1865, 14-25 .

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Application

Application	Comment	Organism
medicine	in Pemt-/- mice, treatment with vitamin E (0.5 g/kg) for 3 weeks improves very low-density lipoprotein-triglyceride secretion and normalizes cholesterol metabolism, but fails to reduce hepatic triglyceride content. Vitamin E treatment is able to reduce hepatic oxidative stress, inflammation and fibrosis. Pemt-/- mice fed a high-fat diet show abnormal ceramide metabolism, with elevation of ceramides and other sphingolipids and higher expression of mRNAs for acid ceramidase (Asah1) and ceramide kinase (Cerk)	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61907	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
physiological function	in Pemt-/- mice, treatment with vitamin E (0.5 g/kg) for 3 weeks improves very low-density lipoprotein-triglyceride secretion and normalizes cholesterol metabolism, but fails to reduce hepatic triglyceride content. Vitamin E treatment is able to reduce hepatic oxidative stress, inflammation and fibrosis. Pemt-/- mice fed a high-fat diet show abnormal ceramide metabolism, with elevation of ceramides and other sphingolipids and higher expression of mRNAs for acid ceramidase (Asah1) and ceramide kinase (Cerk)	Mus musculus

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Release 2023.1 (January 2023)