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Literature summary for 2.1.1.17 extracted from

  • Morita, S.Y.; Ikeda, N.; Horikami, M.; Soda, K.; Ishihara, K.; Teraoka, R.; Terada, T.; Kitagawa, S.
    Effects of phosphatidylethanolamine N-methyltransferase on phospholipid composition, microvillus formation and bile salt resistance in LLC-PK1 cells (2011), FEBS J., 278, 4768-4781.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
a LLC-PK1 cell line stably expressing PEMT shorter isoform (LLC-PK1 /PEMT) is established Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBM1
-
-

Synonyms

Synonyms Comment Organism
PEMT shorter isoform
-
Homo sapiens
phosphatidylethanolamine N-methyltransferase
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Homo sapiens

General Information

General Information Comment Organism
physiological function expression of PEMT increases the cellular phosphatidylcholine (PC) content, lowers the phosphatidylethanolamine (PE) content, but has no effect on the sphingomyelin content. Consequently, PEMT expression leads to reductions in PE/PC and sphingomyelin /PC ratios. PEMT expression enhances the resistance to duramycin and lysenin. PEMT expression increases the diameter of microvilli. The expression of PEMT results in reduced resistance to unconjugated bile salts, but in increased resistance to conjugated bile salts Homo sapiens