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Literature summary for 2.1.1.17 extracted from
- Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology (2007), J. Biol. Chem., 282, 33237-33241.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the PEMT gene is localized to chromosome 11 and spans 25 kb with seven exons and six introns, expression analysis | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of Pemt-/- mice lacking all enzyme activity, but with no abnormal phenotype, normal hepatocyte morphology, normal plasma lipid levels, and no differences in bile composition compared to the wild-type mice, but the phenotype is altered after withdrawal of phosphatidylcholine and production of it, overview. In the liver-specific CTP:phosphocholine cytidylyltransferase alpha knock-out mice, PEMT activity is increased nearly 2fold above control levels. The double knockout mutant shows a dramatic decrease in hepatic phosphatidylcholine, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Mus musculus | 5789 | - |
| mitochondrial membrane | - |
Mus musculus | 31966 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | physiological functions of phosphatidylcholine, mutational analysis, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | physiological functions of phosphatidylcholine, mutational analysis, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PEMT | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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