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Literature summary for 2.1.1.17 extracted from

  • Hartz, C.S.; Nieman, K.M.; Jacobs, R.L.; Vance, D.E.; Schalinske, K.L.
    Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats (2006), J. Nutr., 136, 3005-3009.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male Sprague-Dawley rats of 125-149 g. Diabetes and all-trans-retinoic acid administration decrease the hepatic phosphatidylethanolamine:phosphatidylcholine ratio by 37% compared to control values
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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the activity of phosphatidylethanolamine N-methyltransferase increases (58% higher on day 5, 72% higher on day 7) over 7 d following the injection of streptozotocin (injection of 60 mg/kg on day 0). Diabetes increases the phosphatidylethanolamine N-methyltransferase activity and abundance. Administration of all-trans-retinoic acid alone or in combination with streptozotocin has no effect on phosphatidylethanolamine N-methyltransferase activity. Phosphatidylethanolamine N-methyltransferase activity and abundance in the streptozotocin + insulin group is not significantly different from control values. The enzymatic activity of phosphatidylethanolamine N-methyltransferase is determined by measuring the incorporation of radiolabled methyl groups from S-adenosyl-L-[methyl-3H]methionine into phospholipids. Rattus norvegicus

Synonyms

Synonyms Comment Organism
PEMT
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Rattus norvegicus