Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paramecium bursaria Chlorella virus 1 | O41156 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Paramecium bursaria Chlorella virus 1 | dTMP + tetrahydrofolate + FAD | dUMP binding accelerates the O2-insensitive half-reaction between NADPH and FAD by over four orders of magnitude to about 30 per s. Although dUMP does not have a direct role in FAD reduction, any turnover with molecular O2 requires its presence. Inversely, NADPH accommodation accelerates dUMP binding about 3fold and apparently precedes dUMP binding under physiological conditions. In the oxidative half-reaction, excess N5,N10-methylene-5,6,7,8-tetrahydrofolate reoxidizes FADH2 within 1 ms, thus very efficiently competing with FADH2 oxidation by O2 | ? |
Synonyms | Comment | Organism |
---|---|---|
A674R | - |
Paramecium bursaria Chlorella virus 1 |