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Literature summary for 2.1.1.148 extracted from

  • Leduc, D.; Escartin, F.; Nijhout, H.F.; Reed, M.C.; Liebl, U.; Skouloubris, S.; Myllykallio, H.
    Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria (2007), J. Bacteriol., 189, 8537-8545.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rhodobacter capsulatus Rhodobacter capsulatus ThyX is required for de novo thymidylate synthesis dTMP + tetrahydrofolate + FAD
-
?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rhodobacter capsulatus MT1131 Rhodobacter capsulatus ThyX is required for de novo thymidylate synthesis dTMP + tetrahydrofolate + FAD
-
?

Organism

Organism UniProt Comment Textmining
Rhodobacter capsulatus
-
-
-
Rhodobacter capsulatus MT1131
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
Rhodobacter capsulatus dTMP + tetrahydrofolate + FAD
-
?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rhodobacter capsulatus ThyX is required for de novo thymidylate synthesis Rhodobacter capsulatus dTMP + tetrahydrofolate + FAD
-
?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
Rhodobacter capsulatus MT1131 dTMP + tetrahydrofolate + FAD
-
?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rhodobacter capsulatus ThyX is required for de novo thymidylate synthesis Rhodobacter capsulatus MT1131 dTMP + tetrahydrofolate + FAD
-
?

Synonyms

Synonyms Comment Organism
flavin-dependent thymidylate synthase X
-
Rhodobacter capsulatus
ThyX
-
Rhodobacter capsulatus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rhodobacter capsulatus
NAD(P)H
-
Rhodobacter capsulatus