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Literature summary for 2.1.1.148 extracted from
- Thymidyl biosynthesis enzymes as antibiotic targets (2007), Appl. Microbiol. Biotechnol., 74, 282-289.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | residues His53, Glu190, Arg90, and Arg182 are essential for TS activity | Paramecium bursaria Chlorella virus-1 |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
| crystal structure shows certain small structural differences in the active site when compared with either bacterial FDTS | Paramecium bursaria Chlorella virus-1 |
| crystal structure shows no structural similarity with classical TS | Thermotoga maritima |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | 5-fluorouracil is not a potential inhibitor | Paramecium bursaria Chlorella virus-1 | |
| NADPH | inhibits FDTS at high concentrations at all temperatures, NADPH may not be the natural reducing agent of FDTS | Thermotoga maritima |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
| Chlamydia trachomatis | - |
- |
- |
| Clostridium botulinum | - |
- |
- |
| Helicobacter pylori | - |
- |
- |
| Mycobacterium leprae | - |
- |
- |
| Mycobacterium tuberculosis | P9WG57 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WG57 | - |
- |
| no activity in Homo sapiens | - |
- |
- |
| Paramecium bursaria Chlorella virus-1 | - |
- |
- |
| Pyrococcus furiosus | - |
- |
- |
| Rickettsia sp. | - |
- |
- |
| Thermotoga maritima | - |
- |
- |
| Treponema palladium | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia trachomatis | dTMP + tetrahydrofolate + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Helicobacter pylori | dTMP + tetrahydrofolate + FAD | - |
? | |
| additional information | mRNA binding traits | Pyrococcus furiosus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Thermotoga maritima |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FDTS | - |
Chlamydia trachomatis |
| FDTS | - |
Pyrococcus furiosus |
| FDTS | - |
Mycobacterium leprae |
| FDTS | - |
Helicobacter pylori |
| FDTS | - |
Thermotoga maritima |
| FDTS | - |
Clostridium botulinum |
| FDTS | - |
Rickettsia sp. |
| FDTS | - |
Bacillus anthracis |
| FDTS | - |
Paramecium bursaria Chlorella virus-1 |
| FDTS | - |
Treponema palladium |
| FDTS | - |
Mycobacterium tuberculosis |
| flavin-dependent thymidylate synthase | - |
Chlamydia trachomatis |
| flavin-dependent thymidylate synthase | - |
Pyrococcus furiosus |
| flavin-dependent thymidylate synthase | - |
Mycobacterium leprae |
| flavin-dependent thymidylate synthase | - |
Helicobacter pylori |
| flavin-dependent thymidylate synthase | - |
Thermotoga maritima |
| flavin-dependent thymidylate synthase | - |
Clostridium botulinum |
| flavin-dependent thymidylate synthase | - |
Rickettsia sp. |
| flavin-dependent thymidylate synthase | - |
Bacillus anthracis |
| flavin-dependent thymidylate synthase | - |
Paramecium bursaria Chlorella virus-1 |
| flavin-dependent thymidylate synthase | - |
Treponema palladium |
| flavin-dependent thymidylate synthase | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Helicobacter pylori | |
| NADH | - |
Helicobacter pylori | |
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