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Literature summary for 2.1.1.148 extracted from
- Mechanistic studies of a flavin-dependent thymidylate synthase (2004), Biochemistry, 43, 10295-10301.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the unique mechanism of FDTS makes it an attractive target for antibiotic drug development | Thermotoga maritima |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Thermotoga maritima |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Thermotoga maritima | the enzyme is essential to DNA replication | ? | - |
? | |
| additional information | Thermotoga maritima DSM 3109 | the enzyme is essential to DNA replication | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermotoga maritima | Q9WYT0 | TM0449 | - |
| Thermotoga maritima DSM 3109 | Q9WYT0 | TM0449 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is essential to DNA replication | Thermotoga maritima | ? | - |
? | |
| additional information | the enzyme is essential to DNA replication | Thermotoga maritima DSM 3109 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FDTS | - |
Thermotoga maritima |
| flavin-dependent TS | - |
Thermotoga maritima |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade | Thermotoga maritima | |
| NADPH | the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade | Thermotoga maritima | |
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Release 2023.1 (January 2023)
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