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Literature summary for 2.1.1.148 extracted from
- Complementing thymidylate synthase (2003), Structure, 11, 607-608.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NADH | required to reduce bound FAD | Dictyostelium discoideum |  |
| NADH | required to reduce bound FAD | Thermotoga maritima | |
| NADPH | required to reduce bound FAD | Dictyostelium discoideum | |
| NADPH | required to reduce bound FAD | Thermotoga maritima | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | Dictyostelium discoideum | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | Thermotoga maritima | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | - |
- |
- |
| Thermotoga maritima | Q9WYT0 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Dictyostelium discoideum | dTMP + tetrahydrofolate + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Thermotoga maritima | dTMP + tetrahydrofolate + FAD | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | tightly bound, four molecules per tetramer | Dictyostelium discoideum | |
| FAD | tightly bound, four molecules per tetramer | Thermotoga maritima | |
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