Literature summary for 2.1.1.103 extracted from

Bobenchik, A.M.; Witola, W.H.; Augagneur, Y.; Nic Lochlainn, L.; Garg, A.; Pachikara, N.; Choi, J.Y.; Zhao, Y.O.; Usmani-Brown, S.; Lee, A.; Adjalley, S.H.; Samanta, S.; Fidock, D.A.; Voelker, D.R.; Fikrig, E.; Ben Mamoun, C.
Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission (2013), Proc. Natl. Acad. Sci. USA, 110, 18262-18267.

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Inhibitors

Inhibitors	Comment	Organism	Structure
NSC-109268	-	Plasmodium falciparum
NSC-125034	-	Plasmodium falciparum
NSC-150080	-	Plasmodium falciparum
NSC-158011	competitive inhibitor	Plasmodium falciparum
NSC-22225	-	Plasmodium falciparum
NSC-310551	-	Plasmodium falciparum
NSC-323241	-	Plasmodium falciparum
NSC-348401	-	Plasmodium falciparum
NSC-39225	-	Plasmodium falciparum
NSC-641296	-	Plasmodium falciparum
NSC-668394	-	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Plasmodium falciparum	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + ethanolamine phosphate	Plasmodium falciparum	-	S-adenosyl-L-homocysteine + N-methylethanolamine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8IDQ9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + ethanolamine phosphate	-	Plasmodium falciparum	S-adenosyl-L-homocysteine + N-methylethanolamine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphoethanolamine methyltransferase	-	Plasmodium falciparum
PMT	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0008	-	at pH 8.6 and 37°C	Plasmodium falciparum	NSC-22225
0.005	-	at pH 8.6 and 37°C	Plasmodium falciparum	NSC-39225

General Information

General Information	Comment	Organism
malfunction	parasites lacking the enzyme are incapable of producing mature gametocytes and are not transmitted to mosquitoes	Plasmodium falciparum
physiological function	the enzyme is required for gametocyte development, maturation, and transmission to mosquitoes	Plasmodium falciparum

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Release 2023.1 (January 2023)