Literature summary for 2.1.1.103 extracted from

Bobenchik, A.M.; Choi, J.Y.; Mishra, A.; Rujan, I.N.; Hao, B.; Voelker, D.R.; Hoch, J.C.; Mamoun, C.B.
Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay (2010), BMC Biochem., 11, 4-4.

Search for more literature for 2.1.1.103

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21-Codon-Plus cells	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
amodiaquine	complete inhibition at 0.025 mM	Plasmodium falciparum
dodecyltrimethylammonium	25% inhibition at 0.5 mM	Plasmodium falciparum
hexadecyltrimethylammonium	about 50% inhibition at 0.1 mM	Plasmodium falciparum
miltefosine	about 60% inhibition at 0.1 mM, complete loss of activity at 0.15 mM	Plasmodium falciparum
additional information	not inhibited by 2,3-dichloro-methylbenzyl-amine, chloroquine, and dodecyltrimethylammonium at concentrations up to 0.1 mM	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography, gel filtration	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 S-adenosyl-L-methionine + phosphoethanolamine	-	Plasmodium falciparum	3 S-adenosyl-L-homocysteine + phosphocholine	-	?

Synonyms

Synonyms	Comment	Organism
phosphoethanolamine methyltransferase	-	Plasmodium falciparum
PMT	-	Plasmodium falciparum

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Release 2023.1 (January 2023)