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Literature summary for 2.1.1.103 extracted from
- Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase (2007), Eukaryot. Cell, 6, 1618-1624.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene PfPMT, expression analysis | Plasmodium falciparum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme expression is suppressed by choline | Plasmodium falciparum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + phosphoethanolamine | Plasmodium falciparum | the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline | S-adenosyl-L-homocysteine + methylethanolamine phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
gene PfPMT | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + phosphoethanolamine | - |
Plasmodium falciparum | S-adenosyl-L-homocysteine + methylethanolamine phosphate | - |
? | |
| S-adenosyl-L-methionine + phosphoethanolamine | the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline | Plasmodium falciparum | S-adenosyl-L-homocysteine + methylethanolamine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pfpmt | - |
Plasmodium falciparum |
| phosphoethanolamine methyltransferase | - |
Plasmodium falciparum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Plasmodium falciparum | |
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