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Literature summary for 2.1.1.100 extracted from

  • Teh, J.T.; Zhu, W.L.; Ilkayeva, O.R.; Li, Y.; Gooding, J.; Casey, P.J.; Summers, S.A.; Newgard, C.B.; Wang, M.
    Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism (2015), Oncogene, 34, 3296-3304.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cysmethynil
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Homo sapiens
-
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
Homo sapiens S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?

Synonyms

Synonyms Comment Organism
Icmt
-
Homo sapiens
isoprenylcysteine carboxylmethyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition reduces the function of mitochondrial oxidative phosphorylation in cancer cells. Enzyme inhibition decreases cellular ATP and depletes critical tricarboxylic acid cycle metabolites, leading to suppression of cell anabolism and growth, and marked autophagy Homo sapiens
physiological function the enzyme regulates mitochondrial respiration and cancer cell metabolism Homo sapiens