Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2-(2-((benzyloxy)methyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(2-(phenoxymethyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(2-(phenylthio)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(2-phenoxybenzamido)-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(2-phenoxybenzamido)-3-(undecylthio)propanoic acid | - |
Homo sapiens | |
(R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R)-2-(dibenzo[b,d]furan-4-carboxamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)-propanoic acid | - |
Homo sapiens | |
(R)-2-(N-methyl-2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
(R,E)-3-((3,7-dimethylocta-2,6-dien-1-yl)thio)-2-(2-phenoxybenzamido)propanoic acid | - |
Homo sapiens | |
(S)-2-(2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | - |
Homo sapiens | |
2-phenoxy-phenylfarnesylcysteine | low micromolar inhibitor | Homo sapiens | |
N-[2-(benzyloxy)benzoyl]-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | - |
Homo sapiens | |
S-{(2E)-3-[2-(biphenyl-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl}-N-(2-phenoxybenzoyl)-L-homocysteine | low micromolar inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
isoprenylcysteine carboxyl methyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0025 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | S-{(2E)-3-[2-(biphenyl-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl}-N-(2-phenoxybenzoyl)-L-homocysteine | |
0.0062 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | 2-phenoxy-phenylfarnesylcysteine | |
0.0067 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(N-methyl-2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.0078 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (S)-2-(2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.0134 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | N-[2-(benzyloxy)benzoyl]-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | |
0.0147 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-(phenylthio)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.0226 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.038 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.038 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-phenoxybenzamido)-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propanoic acid | |
0.049 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-((benzyloxy)methyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-thio)propanoic acid | |
0.058 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(dibenzo[b,d]furan-4-carboxamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)-propanoic acid | |
0.063 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.075 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-(phenoxymethyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid | |
0.149 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R,E)-3-((3,7-dimethylocta-2,6-dien-1-yl)thio)-2-(2-phenoxybenzamido)propanoic acid | |
0.21 | - |
in 100 mM Tris-HCl, pH 7.5, at 30°C | Homo sapiens | (R)-2-(2-phenoxybenzamido)-3-(undecylthio)propanoic acid |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is responsible for the last common step of the posttranslational processing pathway of CaaX proteins | Homo sapiens |