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Literature summary for 2.1.1.100 extracted from

  • Baron, R.A.; Casey, P.J.
    Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt) (2004), BMC Biochem., 5, 19.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.100

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-S-farnesyl-L-cysteine methylester noncompetitive inhibition with respect to biotin-S-farnesyl-L-cysteine, mixed type inhibition with respect to S-adenosyl-L-methionine Homo sapiens
S-adenosyl-L-homocysteine competitive inhibitor with respect to S-adenosyl-L-methionine Homo sapiens
S-Farnesylthioacetic acid dead-end inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
 biotin-S-farnesyl-L-cysteine
-
 Homo sapiens
0.0078
-
 S-adenosyl-L-methionine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + N-biotinyl-S-farnesyl-L-cysteine methyl ester S-adenosyl-L-homocysteine is the final product released ?

Synonyms

Synonyms Comment Organism
Icmt
-
 Homo sapiens
isoprenylcysteine carboxylmethyltransferase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00117
-
 S-Farnesylthioacetic acid
-
 Homo sapiens
0.0021
-
 N-acetyl-S-farnesyl-L-cysteine methyl ester with respect to biotin-S-farnesyl-L-cysteine Homo sapiens
0.00243
-
 N-acetyl-S-farnesyl-L-cysteine methyl ester with respect to S-adenosyl-L-methionine Homo sapiens
0.00354
-
 S-adenosyl-L-homocysteine with respect to S-adenosyl-L-methionine Homo sapiens
0.00359
-
 S-adenosyl-L-homocysteine with respect to biotin-S-farnesyl-L-cysteine Homo sapiens