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Literature summary for 2.1.1.100 extracted from

  • Volker, C.; Miller, R.A.; McCleary, W.R.; Rao, A.; Poenie, M.; Backer, J.M.; Stock, J.B.
    Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction (1991), J. Biol. Chem., 266, 21515-21522.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Rattus norvegicus
0.04
-
N-acetyl-S-(E,E)-farnesyl-D-cysteine
-
Rattus norvegicus
1
-
N-acetyl-S-(E)-geranyl-L-cysteine
-
Rattus norvegicus
5
-
N-acetyl-S-3,3-dimethylalkyl-L-cysteine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Rattus norvegicus carboxyl methylation may play a role in the regulation of receptor mediated signal transduction processes in eukaryotic cells S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Rattus norvegicus
-
fibroblast
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetyl-S-(E)-geranyl-L-cysteine
-
Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-S-(E)-geranyl-L-cysteine methyl ester
-
?
S-adenosyl-L-methionine + N-acetyl-S-3,3-dimethylalkyl-L-cysteine
-
Rattus norvegicus S-adenosyl-L-homocysteine + S-methyl N-acetyl-S-3,3-dimethylalkyl-L-cysteine
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine gamma-subunit of heterotrimeric G-proteins Rattus norvegicus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine ras-proteins Rattus norvegicus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine carboxyl methylation may play a role in the regulation of receptor mediated signal transduction processes in eukaryotic cells Rattus norvegicus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-D-cysteine
-
Rattus norvegicus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-D-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Rattus norvegicus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-3,3-dimethylallyl-L-cysteine
-
Rattus norvegicus S-adenosylhomocysteine + N-acetyl-S-3,3-dimethylallyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?