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Literature summary for 2.1.1.1 extracted from

  • Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.
    Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis (2009), Pharmacol. Rep., 61, 76-85.
    View publication on PubMed
Search for more literature for 2.1.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Mus musculus
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
S-adenosyl-L-methionine + nicotinamide Mus musculus C57/BL6J
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice
-
Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
adrenal gland
-
 Mus musculus
-
brain
-
 Mus musculus
-
carcinoma cell
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview Mus musculus
-
lung
-
 Mus musculus
-
placenta
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 4-methylnicotinamide assay for fluorometric determination of enzyme activity Mus musculus S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
 ?
S-adenosyl-L-methionine + 4-methylnicotinamide assay for fluorometric determination of enzyme activity Mus musculus C57/BL6J S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
 ?
S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus C57/BL6J S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
NNMT
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
 assay at, substrate 4-methoxybenzaldehyde Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels up

General Information

General Information Comment Organism
physiological function progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels Mus musculus