Application | Comment | Organism |
---|---|---|
diagnostics | NNMT is useful as a biomarker of lung cancer, stages I-III. The sensitivity of the detection in non-small cell lung cancer cells at 90% specficity increases from 25% to 32% when NNMT is used in combination with carcinoembryonic antigen, method development, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene NNMT, expression fo the GST-tagged enzyme in Escherichia coli strain JM109 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged enzyme from Escherichia coli strain JM109 by glutathione affinity chromatography and cleavage of the tag by thrombin | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
lung cancer cell | serum levels of NNMT are signficantly higher in lung cancer patients, overview | Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
serum | sera from 24 healthy individuals, from 113 non-small cell lung cancer patients undergoing surgery, and from 50 nonneoplastic lung disease patients with chronic obstructive pulmonary disease. Serum levels of NNMT are signficantly higher in lung cancer patients, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Homo sapiens |