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Literature summary for 2.1.1.1 extracted from
- Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems (2008), J. Biol. Chem., 283, 17147-17157.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no activation by beta-naphthoflavone and ciprofibrate | Mus musculus | |
| Phenobarbital | activates 3-4fold in liver micorosomes | Mus musculus |  |
| Phenobarbital | activates the enzyme in liver microsomes | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clofibrate | inhibits the enzyme in liver micorosomes | Mus musculus | |
| Clofibrate | inhibits the enzyme in liver microsomes | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NNMT | - |
Mus musculus |
| NNMT | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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