Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
thioredoxin 1 | - |
Homo sapiens | |
0.03 | - |
ATP | - |
Homo sapiens | |
1.8 | - |
GSH | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | Homo sapiens | Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with CTP, UTP, dCTP, or dTTP | Homo sapiens | ? | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | - |
Mus musculus | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | - |
Rattus norvegicus | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | both glutathione and thioredoxin are potential physiological electron donors | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + GSH | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + GSSG | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + thioredoxin 1 | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + thioredoxin 1 disulfide | - |
r | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH | both glutathione and thioredoxin are potential physiological electron donors | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dGTP + 2 R-SH | both glutathione and thioredoxin are potential physiological electron donors | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + GTP + 2 R-SH | both glutathione and thioredoxin are potential physiological electron donors | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Srx | - |
Mus musculus |
Srx | - |
Homo sapiens |
Srx | - |
Rattus norvegicus |