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Literature summary for 1.8.5.7 extracted from

  • Lam, L.; Zhang, Z.; Board, P.; Xun, L.
    Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S-glutathionyl-hydroquinone reductases (2012), Biochemistry, 51, 5014-5021.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
0.004
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
0.0067
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae
0.012
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
0.017
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
0.034
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
0.034
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
0.035
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
0.07
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
0.13
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
0.15
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
0.19
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
0.24
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
0.35
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
0.37
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
0.39
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
0.43
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
0.84
-
glutathione pH 8.0, 23°C Escherichia coli
0.88
-
glutathione pH 8.0, 23°C Cupriavidus necator
1.2
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
-
-
Cupriavidus necator JMP 134-1
-
-
-
Escherichia coli P42620
-
-
Saccharomyces cerevisiae
-
-
-
Sphingobium chlorophenolicum
-
-
-
Sphingobium chlorophenolicum ATCC 29327
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Cupriavidus necator glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Escherichia coli glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Cupriavidus necator glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Escherichia coli glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + hydroxy-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Saccharomyces cerevisiae glutathione disulfide + menadiol
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Cupriavidus necator glutathione disulfide + menadiol
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Escherichia coli glutathione disulfide + menadiol
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Cupriavidus necator JMP 134-1 glutathione disulfide + menadiol
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Sphingobium chlorophenolicum glutathione disulfide + menadione
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + menadione
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + methyl-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Cupriavidus necator glutathione disulfide + methyl-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + methyl-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Escherichia coli glutathione disulfide + methyl-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + methyl-p-hydroquinone
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + methyl-p-hydroquinone
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Saccharomyces cerevisiae ?
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Cupriavidus necator ?
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Sphingobium chlorophenolicum ?
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Escherichia coli ?
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Sphingobium chlorophenolicum ATCC 29327 ?
-
?
additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Cupriavidus necator JMP 134-1 ?
-
?

Synonyms

Synonyms Comment Organism
ECM4
-
Saccharomyces cerevisiae
pcpF
-
Sphingobium chlorophenolicum
yqjG
-
Cupriavidus necator
yqjG
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
4.6
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
4.9
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
7.1
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
7.2
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
7.5
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
8.4
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
11
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
13
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
13
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
14
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum
14
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
14
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
14
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae
15
-
glutathione pH 8.0, 23°C Escherichia coli
15
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
19
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
22
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
31
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
37
-
glutathione pH 8.0, 23°C Cupriavidus necator

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
12
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum
15
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
18
-
glutathione pH 8.0, 23°C Escherichia coli
21
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
26
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
35
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
36
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
42
-
glutathione pH 8.0, 23°C Cupriavidus necator
56
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
91
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
130
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
160
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
210
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
210
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
410
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
590
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
760
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
1200
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
1400
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
2100
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae