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Literature summary for 1.8.4.2 extracted from
- Glutathione-insulin transhydrogenase (protein-disulfide interchange enzyme) (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 753-765.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Mus musculus |  |
| Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Homo sapiens | |
| Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Rattus norvegicus | |
| Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Bos taurus | |
| EDTA | and other chelating agents activate | Mus musculus | |
| EDTA | and other chelating agents activate | Homo sapiens | |
| EDTA | and other chelating agents activate | Rattus norvegicus | |
| EDTA | and other chelating agents activate | Bos taurus | |
| additional information | overview | Mus musculus | |
| additional information | overview | Homo sapiens | |
| additional information | overview | Rattus norvegicus | |
| additional information | overview | Bos taurus | |
| phosphatidylethanolamine | activates at low concentration | Mus musculus | |
| phosphatidylethanolamine | activates at low concentration | Homo sapiens | |
| phosphatidylethanolamine | activates at low concentration | Rattus norvegicus | |
| phosphatidylethanolamine | activates at low concentration | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Bos taurus | |
| Aprotinin | - |
Homo sapiens | |
| Aprotinin | - |
Mus musculus | |
| Aprotinin | - |
Rattus norvegicus | |
| bacitracin | - |
Bos taurus | |
| bacitracin | - |
Homo sapiens | |
| bacitracin | - |
Mus musculus | |
| bacitracin | - |
Rattus norvegicus | |
| Ca2+ | slight | Bos taurus | |
| Ca2+ | slight | Homo sapiens | |
| Ca2+ | slight | Mus musculus | |
| Ca2+ | slight | Rattus norvegicus | |
| Cu2+ | - |
Bos taurus | |
| Cu2+ | - |
Homo sapiens | |
| Cu2+ | - |
Mus musculus | |
| Cu2+ | - |
Rattus norvegicus | |
| Hg2+ | - |
Bos taurus | |
| Hg2+ | - |
Homo sapiens | |
| Hg2+ | - |
Mus musculus | |
| Hg2+ | - |
Rattus norvegicus | |
| lysolecithin | - |
Bos taurus | |
| lysolecithin | - |
Homo sapiens | |
| lysolecithin | - |
Mus musculus | |
| lysolecithin | - |
Rattus norvegicus | |
| additional information | overview | Bos taurus | |
| additional information | overview | Homo sapiens | |
| additional information | overview | Mus musculus | |
| additional information | overview | Rattus norvegicus | |
| Ni2+ | slight | Bos taurus | |
| Ni2+ | slight | Homo sapiens | |
| Ni2+ | slight | Mus musculus | |
| Ni2+ | slight | Rattus norvegicus | |
| phosphatidic acid | - |
Bos taurus | |
| phosphatidic acid | - |
Homo sapiens | |
| phosphatidic acid | - |
Mus musculus | |
| phosphatidic acid | - |
Rattus norvegicus | |
| Se2+ | - |
Bos taurus | |
| Se2+ | - |
Homo sapiens | |
| Se2+ | - |
Mus musculus | |
| Se2+ | - |
Rattus norvegicus | |
| Zn2+ | - |
Bos taurus | |
| Zn2+ | - |
Homo sapiens | |
| Zn2+ | - |
Mus musculus | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Mus musculus | |
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Bos taurus | |
| 0.01 | - |
Insulin | - |
Mus musculus | |
| 0.01 | - |
Insulin | - |
Homo sapiens | |
| 0.01 | - |
Insulin | - |
Rattus norvegicus | |
| 0.01 | - |
Insulin | - |
Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| membrane | bound to | Rattus norvegicus | 16020 | - |
| microsome | majority of the enzyme located at | Rattus norvegicus | - |
- |
| microsome | weakly bound on cisternal surface of microsomes via phospholipids | Rattus norvegicus | - |
- |
| secretory granule | of alpha and beta cells of islets of Langerhans | Rattus norvegicus | 30141 | - |
| zymogen granule | of acinar cells | Rattus norvegicus | 42588 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
3 molecular forms: MW 56000 is the major form, MW 51000 is active and only present in spleen, possibly a proteolytic product of 56000 MW protein, MW 67000 is possibly a precursor of 56000 MW protein | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | Mus musculus | physiological function | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Homo sapiens | physiological function | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Rattus norvegicus | physiological function | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Bos taurus | physiological function | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Mus musculus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Homo sapiens | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Rattus norvegicus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Bos taurus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Mus musculus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Homo sapiens | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Rattus norvegicus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Bos taurus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Mus musculus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Homo sapiens | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Rattus norvegicus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Bos taurus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phospholipoprotein | - |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| diaphragm | - |
Rattus norvegicus | - |
| erythrocyte | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| intestine | - |
Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| lens | - |
Rattus norvegicus | - |
| leukocyte | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| additional information | - |
Mus musculus | - |
| additional information | - |
Rattus norvegicus | - |
| additional information | - |
Bos taurus | - |
| additional information | higher activity in mononuclear cells than in polymorphonuclear cells | Homo sapiens | - |
| pancreas | - |
Mus musculus | - |
| pancreas | - |
Homo sapiens | - |
| pancreas | - |
Rattus norvegicus | - |
| pancreas | - |
Bos taurus | - |
| placenta | - |
Rattus norvegicus | - |
| retina | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
| thymus | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay methods | Mus musculus |
| additional information | - |
assay methods | Homo sapiens |
| additional information | - |
assay methods | Rattus norvegicus |
| additional information | - |
assay methods | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dimercaptopropanol + protein disulfide | - |
Mus musculus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
| 2,3-dimercaptopropanol + protein disulfide | - |
Homo sapiens | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
| 2,3-dimercaptopropanol + protein disulfide | - |
Rattus norvegicus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
| 2,3-dimercaptopropanol + protein disulfide | - |
Bos taurus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
| cysteamine + protein disulfide | - |
Mus musculus | ? | - |
? | |
| cysteamine + protein disulfide | - |
Homo sapiens | ? | - |
? | |
| cysteamine + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
| cysteamine + protein disulfide | - |
Bos taurus | ? | - |
? | |
| dihydrolipoic acid + protein disulfide | - |
Mus musculus | ? | - |
? | |
| dihydrolipoic acid + protein disulfide | - |
Homo sapiens | ? | - |
? | |
| dihydrolipoic acid + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
| dihydrolipoic acid + protein disulfide | - |
Bos taurus | ? | - |
? | |
| GSH + insulin | proinsulin | Mus musculus | GSSG + reduced insulin chain A and B | - |
? | |
| GSH + insulin | proinsulin | Homo sapiens | GSSG + reduced insulin chain A and B | - |
? | |
| GSH + insulin | proinsulin | Rattus norvegicus | GSSG + reduced insulin chain A and B | - |
? | |
| GSH + insulin | proinsulin | Bos taurus | GSSG + reduced insulin chain A and B | - |
? | |
| GSH + oxytoxin | - |
Mus musculus | ? | - |
? | |
| GSH + oxytoxin | - |
Homo sapiens | ? | - |
? | |
| GSH + oxytoxin | - |
Rattus norvegicus | ? | - |
? | |
| GSH + oxytoxin | - |
Bos taurus | ? | - |
? | |
| GSH + protein disulfide | - |
Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | - |
Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | - |
Bos taurus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | physiological function | Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | physiological function | Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | physiological function | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | physiological function | Bos taurus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | reductive degradation and assembly of proteins | Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | reductive degradation and assembly of proteins | Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | reductive degradation and assembly of proteins | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | reductive degradation and assembly of proteins | Bos taurus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Bos taurus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Bos taurus | GSSG + protein-dithiol | - |
? | |
| GSH + vasopressin | - |
Mus musculus | ? | - |
? | |
| GSH + vasopressin | - |
Homo sapiens | ? | - |
? | |
| GSH + vasopressin | - |
Rattus norvegicus | ? | - |
? | |
| GSH + vasopressin | - |
Bos taurus | ? | - |
? | |
| additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Mus musculus | ? | - |
? | |
| additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Homo sapiens | ? | - |
? | |
| additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Rattus norvegicus | ? | - |
? | |
| additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Bos taurus | ? | - |
? | |
| additional information | immunoglobulin IgM and IgG | Mus musculus | ? | - |
? | |
| additional information | immunoglobulin IgM and IgG | Homo sapiens | ? | - |
? | |
| additional information | immunoglobulin IgM and IgG | Rattus norvegicus | ? | - |
? | |
| additional information | immunoglobulin IgM and IgG | Bos taurus | ? | - |
? | |
| additional information | scrambled lysozyme | Mus musculus | ? | - |
? | |
| additional information | scrambled lysozyme | Homo sapiens | ? | - |
? | |
| additional information | scrambled lysozyme | Rattus norvegicus | ? | - |
? | |
| additional information | scrambled lysozyme | Bos taurus | ? | - |
? | |
| additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Mus musculus | ? | - |
? | |
| additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Homo sapiens | ? | - |
? | |
| additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Rattus norvegicus | ? | - |
? | |
| additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Bos taurus | ? | - |
? | |
| additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Mus musculus | ? | - |
? | |
| additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Homo sapiens | ? | - |
? | |
| additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Rattus norvegicus | ? | - |
? | |
| additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GIT | - |
Mus musculus |
| GIT | - |
Homo sapiens |
| GIT | - |
Rattus norvegicus |
| GIT | - |
Bos taurus |
| More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Mus musculus |
| More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Homo sapiens |
| More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Rattus norvegicus |
| More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Bos taurus |
| More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Mus musculus |
| More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Homo sapiens |
| More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Rattus norvegicus |
| More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Bos taurus |
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